They found that while Hydroquinone, Kojic Acid and Arbutin worked very well on mushroom Tyrosinase, they actually didn't work well on human Tyrosinase. -, Maymone, M.B.C. Semin. Esp for melasma and it also reduced a PIH caused by laser resurfacing. HPV can cause cancers of the: Cervix, vagina, and vulva in women Penis external icon in men; Anus external icon in both men and women; Back of the throat, including the base of the tongue and tonsils (oropharynx), in both men and women Cancer usually takes years, even decades, to develop after a person gets HPV. Par la suite, nous avons valu lefficacit et la tolrance dun rgime de soins du visage typique contenant du Thiamidol dans le cadre dune tude en situation relle. It contains high and low molecular Hyaluronic Acid and Arctiin to plump up deep wrinkles and improve skin elasticity, as well as Thiamidol for actively reducing age spots, EUCERIN HYALURON-FILLER + ELASTICITY 3D SERUM, Leaves the skin feeling soft and silky smooth. Data are depicted as meanSEM. In clinical studies, it was shown to improve facial hyperpigmentation, post-inflammatory hyperpigmentation and age spots significantly. Unfortunately, treatment with anti-inflammatory ingredients alone does not prevent the development of hyperpigmented spots. Understanding Melasma-How Can Pharmacology and Cosmetology Procedures and Prevention Help to Achieve Optimal Treatment Results? J. Cosmet. (a) Representative images of a subject at baseline and after 4, 8 and 12weeks of treatment with the Thiamidolcontaining skin care regimen (day cream, night cream and dual serum). Although not all of these side effects may occur, if they do occur they may need medical attention. Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Acta Derm Venereol. Sci. 2020 Society of Cosmetic Scientists and the Socit Franaise de Cosmtologie. Going to keep using it until it's gone. National Library of Medicine Check with your doctor immediately if any of the following side effects occur while taking thalidomide: Some side effects of thalidomide may occur that usually do not need medical attention. Medically reviewed by Drugs.com. Mayo Clin Proc 82 (2007): 638, 18. . For drugs taken in high doses, blisters, edema (swelling), and urticaria . Recently, isobutylamido-thiazolyl-resorcinol (Thiamidol) was described as a very potent inhibitor of human tyrosinase. Its understandable to throw away any of the sunscreens cited in the report. Malheureusement, un traitement par des ingrdients anti-inflammatoires seuls nempche pas le dveloppement de taches hyperpigmentes. Independent studies are how we know something actually works. This is understood ashyperpigmentation,melasma or age spots. Thiamidol is patented by Beiersdorf AG. Likely to have had lots of acne or acne cysts and/or nodules. With increased activation, this enzyme can produce more melanin and the skin can appear darker in some areas. There's a day cream, night cream and spot corrector, all of which have it in their ingredients list (listed under its chemical name Isobutylamido Thiazolyl Resorcinol), but I can't find the % concentration anywhere. Melasma: The need for tailored photoprotection to improve clinical outcomes. National Library of Medicine Am. Read this article to learn how you can use Eucerin products containing Thiamidol to make your skin . An official website of the United States government. Sunscreen is a crucial step in any skincare routine, but some brands might not be living up to their safety promises: In May, an independent lab announced it discovered potentially harmful levels of benzene, a known carcinogen, in several popular sun-care products. If you have a pigment spot that is changing in size, . There isnt any measure of how much benzene is safe to include in sun-care products, though; the FDA established a temporary 2 ppm limit on hand sanitizers during the pandemic, but there is no analogue for SPF. Why Trust Us? Even brands that had certain products with high levels of benzene also had plenty of products that contained none at all, including Neutrogena and Sun Bum. Bookshelf As someone who religiously uses Arbutin and Kojic acid, Im very interested in this. Gordinier ME, Dizon DS "Dyspnea during thalidomide treatment for advanced ovarian cancer." Symptoms. Lapplication de Thiamidol quatre fois par jour, amliore lhyperpigmentation du visage de manire plus significative que deux fois par jour et est bien tolr par les sujets. Thiamidol was the most potent inhibitor of human tyrosinase out of 50 000 screened substances. slurred speech. Thalidomide distribution is restricted through the THALOMID REMS(TM) program (formerly known as the S.T.E.P.S. program). In some cases . 2012 May;92(3):232-5. doi: 10.2340/00015555-1225. doi: 10.1016/j.jid.2019.02.013. Create an account to follow your favorite communities and start taking part in conversations. (a) . Keywords: J. Eur. (182) 3 for 2 on selected Eucerin - cheapest free. Objective. (b) Visibility of hyperpigmentation as determined by selfgrading after 4, 8 and 12weeks of treatment with the Thiamidolcontaining formulation or the vehicle. , Wirya, S.A. et al The impact of skin hyperpigmentation and hyperchromia on quality of life: A crosssectional study. User survey after two weeks. 42.00. Monitor for thromboembolism and consider thromboprophylaxis for individualized cases. . , Lee, E.S. Its the result of 10 years of research and over 50,000 tested ingredients, and you can find it as a key ingredient in many of our skincare products. Facial hyperpigmentation is a common skin issue that can cause embarrassment and affect the quality of life in majority of people. A Narrative Review. My problems are mostly melasma from birth control (stubborn hyperpigmentation on my foreheads and lips for over 7 years now) and additional leftover pigmentation from the summer months. Here's the before and after photo from the study. An innovative dual-action serum with Thiamidol and concentrated Hyaluronic Acid. I'll try this stuff out once I'll be sure the azelaic acid wont work. Epub 2022 Mar 8. There are non-disclosure agreements, or they could bring in an outside team to simply supervise the study, or assess the methodology without ever coming into contact with their precious patented secret ingredient. Lapplication quatre fois par jour a apport une amlioration significative par rapport lapplication deux fois par jour. Keesal N, Wasserman MJ, Bookman A, Lapp V, Weber DA, Keystone EC "Thalidomide in the treatment of refractory rheumatoid arthritis." All four products in the range - a day cream, night cream, serum and spot corrector - contain Thiamidol, an effective and patented ingredient that acts at the root cause of hyperpigmentation by reducing melanin production. Press J to jump to the feed. Eight weeks of regular usage twice a day. Thiamidol; emulsions; isobutylamido-thiazolyl-resorcinol; post-inflammatory hyperpigmentation; skin physiology; spectroscopy. Dans ltude en situation relle (n = 83), tous les paramtres valus, y compris ltat de la peau et la chromamtrie (n = 30) se sont amliors significativement (P < 0.001) par rapport la ligne de base et aux visites prcdentes correspondantes. Neutrogenas UltraSheer Weightless Sunscreen Spray SPF 100, for example, contained the most benzene of the batches tested, with 6.26 ppm, or more than triple the FDAs limit. Already after 2 weeks of treatment, suction blister sites treated with Thiamidol were significantly lighter than control sites and improved throughout the treatment period. It has been clinically and dermatologically proven to reduce dark spots and prevent their re-appearance. (a) Representative examples of suction blisterinduced, Treatment of acneinduced PIH in darkskinned individuals. Studies have shown COVID-19 vaccines . Thiamidol is very gentle, meaning its great for sensitive skin. Heavy or regular alcohol consumption increases the risk of developing cancers of the oral cavity (excluding the lips), pharynx (throat), larynx (voice box), esophagus, liver, breast, colon, and rectum. In a report released May 24, Valisure, a lab and online pharmacy that regularly tests consumer products, explains it analyzed 294 batches of sunscreen and after-sun products from 69 brands. 3. Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body. Lets nerd out over it together. J Natl Cancer Inst 103 (2011): 1572-87, 16. 30ML | 140.00 per 100ML. Some side effects may not be reported. I came across Eucerin's new line of anti-pigment products, containing their patented skin lightening ingredient, Thiamidol. Int J Environ Res Public Health. (a) Skin evenness as determined by the investigator at baseline and after 4, 8 and 12weeks of treatment with the Thiamidolcontaining skin care regimen (day cream, night cream, dual serum). Careers. Arch Dermatol 120 (1984): 1466-70, 8. PMC While benzene is not an ingredient in any of our sunscreen products, it was detected in some samples of the impacted aerosol sunscreen finished products, Johnson & Johnson wrote in a July 14 press release following internal testing. 2022 Sep 24;19(19):12084. doi: 10.3390/ijerph191912084. Isobutylamido thiazolyl resorcinol for prevention of UVB-induced hyperpigmentation. J. Clin. In the study, it says they used 0.2% to get the results shown in the picture, but it also says "a follow-up study showed that concentrations of Thiamidol as low as 0.1% effectively reduced the visibility of age spots". Often appearing on the face, hands and other parts of the body exposed to the sun, age spots are small areas of discolouration (hyperpigmentation) visible on the skin. 2021 Mar;20(3):987-992. doi: 10.1111/jocd.13615. OBJECTIVE. Thiamidol was well-tolerated and well-perceived and represents an effective agent to reduce hyperpigmentation. Un programme de soins de la peau contenant du Thiamidol a significativement amlior la PIH lie lacn sur 12 semaines, comme lont dmontr les mesures de Mexameter, lvaluation par des experts, lauto-valuation des sujets et la photographie mdicale. Duyvendak M, Naunton M, Kingma BJ, Brouwers JR "Thalidomide-associated thrombocytopenia." Reddit and its partners use cookies and similar technologies to provide you with a better experience. The % content is another reason I'm sceptical. In addition to . 2020 Aug;42(4):377-387. doi: 10.1111/ics.12626. Dermatol. See this image and copyright information in PMC. Thalidomide can cause severe birth defects or embryofetal death, even with 1 dose, if taken during pregnancy. This being said, it doesn't necessarily mean it's ineffective. Im curious why the kojic acid and alpha Arbutine didnt help you though. Photodermatol Photoimmunol Photomed. (a) Representative images, Expert rating and selfassessment of facial skin condition. If thiamidol is a more effective ingredient I would consider adding it to my regimen. Last updated on Oct 27, 2022. Using the Eucerin Anti-pigment night cream was a very random buy at boots pharmacy. Rcemment, lisobutylamido-thiazolyl-rsorcinol (Thiamidol) a t dcrit comme un inhibiteur trs puissant de la tyrosinase humaine. Ltude en situation relle tait ouverte, observationnelle, et comprenait trois produits contenant du Thiamidol (soin de jour SPF 30 le matin, srum et soin de nuit le soir). sore throat. (Dermatologists dont usually recommend sprays, anyway, since application can be inconsistent and many people forget to rub them in. Partially because it didn't seem to come with any of hydroquinone's gnarly side effects, like redness, itchiness, dryness, or potential worsening of discoloration, that would cause a user to stop using it. Would you like email updates of new search results? Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1. Symptoms include severe redness on the areas of skin exposed to light, akin to an exaggerated sunburn with severe tenderness. Hamnvik OP, Larsen PR, Marqusee E "Thyroid dysfunction from antineoplastic agents." Melanoma is a type of skin cancer that begins with the skin's melanocytes. Am. 10.1590/abd1806-4841.20142353 In vivo, it was well tolerated and improved melasma significantly. Conclusion: "It usually occurs on the face, predominantly on the cheeks and forehead," she explains, noting that it's usually caused by hormonal changes and/or sun exposure. The effect of skin care formulations containing Thiamidol on acne-related PIH was investigated in two studies, a vehicle-controlled, double-blinded, randomized clinical study and a clinical observational study. Let's be honesthe's probably scrolling through Twitter right now. Along with its needed effects, thalidomide may cause some unwanted effects. Data are depicted as meanSD. Dermatol. Venereol. Conclusion: Thiamidol represents a safe and effective ingredient for cosmetic products against post-inflammatory hyperpigmentation. There has been some studies talking about this ingredient. Conclusion: Scores were assessed after 4, 8 and 12weeks of treatment. sharing sensitive information, make sure youre on a federal Our rating: False. The % content is another reason I'm sceptical. Melanin is the brown pigment that determines the colour of our skin. Accessibility A phenomenon known as the Warburg effect has been known for a century and was thought by Warburg to be the cause of cancer. Gastroenterology 120 (2001): 1567-8, 4. There is ever increasing evidence that energy metabolism is involved in the causation of cancer. Im using niacinamide and Vit C alongside (regularly for roughly a year now) but I think the thiamidol has made a big difference. However, this fake food has now been shown to . Passeron T, Lacour JP, Murr D, Ortonne JP "Thalidomide-induced amenorrhoea: two cases." Eucerin Anti-Pigment Dual Serum contains two separate serums within the same bottle, those being Thiamidol and Hyaluronic Acid. Good luck! . Not only this, but it also improves Thiamidols efficacy. En outre, les donnes fournissent des preuves de ladquation de ce rgime de trois produits base de Thiamidol pour le soin quotidien. Benzene is an organic compound known to be a carcinogen, which means it has been associated with the development of cancers, explains Joshua Zeichner, M.D., director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City. Nat Prod Bioprospect. Using Thiamidol against sun-induced pigment spots. Offer. Its crucial to protect your skin from damaging UV rays, Dr. Zeichner says, which can lead to painful sunburns, premature signs of aging, and skin cancer. It's the Eucerin anti-pigment range. So, of course, I Googled Thiamidol. Careers. It develops in squamous cells, which are the thin, flat cells that make up the outermost layer of your skin . RSULTATS: Aprs 2 semaines de traitement seulement, les sites de bulles de succion traits par du Thiamidol taient significativement plus clairs que les sites-tmoins et avaient montr une amlioration tout au long de la priode de traitement. The site is secure. Squamous cell cancer (SCC), also known as squamous cell carcinoma, is a type of cancer. J. Mol. Subjects self-grading demonstrated that Thiamidol significantly improved the visibility of acne-induced hyperpigmentation compared to the vehicle treatment. That's so interesting you brought this up today, I just read about Thiamidol too and ordered the Eucerin ANTI-PIGMENT - Pigment Reducing Day Cream SPF30 since it has Thiamidol. The objective of this research was to investigate the potential of this compound to prevent PIH induced by epidermal wounding (suction blister) and related to acne. (b) Melanin index scores of lesional and perilesional skin after 4, 8 and 12weeks of treatment. "Benzene is an organic compound known to be a carcinogen, which means it has been associated with the development of cancers," explains Joshua Zeichner, M.D . Furthermore, the data provide evidence for the suitability of this three-product Thiamidol regimen for day-to-day life. Subjects rated the efficacy of the Thiamidol formulation significantly better with regard to overall decreased intensity of dark spots and their overall appearance throughout the study. Epub 2021 Oct 21. muscle cramps in the hands, arms, feet, legs, or face, pain in the chest, groin, or legs, especially the calves, pain, redness, or swelling in the arm or leg, shakiness in the legs, arms, hands, or feet, sores, ulcers, or white spots in the mouth or on the lips, sudden, severe weakness or numbness in the arm or leg, tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area, tingling, burning, numbness, or pain in the hands, arms, feet, or legs, inability to move the arms, legs, or facial muscles, red skin lesions, often with a purple center. Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases. JAMA 296 (2006): 2558-60, 15. So if you inhibit Tyrosinase, you won't produce as much Melanin, so your skin will get lighter. None of the other authors state a conflict of interest. Now, Johnson & Johnson has voluntarily recalled five entire lines of Neutrogena and Aveeno spray sunscreens. Results: I think you had the right instinct to check who made this study, and to raise an eyebrow at their claims. Here's the before and after photo from the study. The Washington Standard / February 28, 2023. I'm trying to tackle some acne pigmentation spots left on my face and I was just about to take the plunge on Hydroquinone when I found this. The descriptive term, benign keratosis, is . Eucerin uses its own patented Thiamidol in the pen. J. Clin. Federal government websites often end in .gov or .mil. For now, we cant be sure. [Ref], Very common (10% or more): Hypocalcemia (95%), anorexia (28%), weight loss (23%), weight gain (22%), Common (1% to 10%): Hypokalemia, hyperlipidemia, Rare (less than 0.1%): Increased appetite, Frequency not reported: Increased appetite, electrolyte abnormalities, hyperkalemia, hypocalcemia, hypoproteinemia, increased lactate dehydrogenase (LDH), decreased phosphorus, Postmarketing reports: Tumor lysis syndrome, hypercalcemia, hyponatremia, hypomagnesemia[Ref], Very common (10% or more): Fatigue (79%), edema (56%), peripheral edema (34%), asthenia (24%), pyrexia/fever (24%), Common (1% to 10%): Accidental injury, chills, infection, pain, malaise, weakness, lethargy, Frequency not reported: Tinnitus, palpable spleen, Postmarketing reports: Sepsis, septic shock, hearing impairment/deafness, hangover effect[Ref], Very common (10% or more): Constipation (55%), nausea (28%), diarrhea (18.7%), dry mouth (12%), oral moniliasis (11.1%), dyspepsia (11%), Common (1% to 10%): Abdominal pain, vomiting, flatulence, Uncommon (0.1% to 1%): Diverticular perforation, peritonitis, Very rare (less than 0.01%): Intestinal obstruction, Frequency not reported: Enlarged abdomen, eructation, Postmarketing reports: Gastrointestinal (GI) perforation, GI hemorrhage, pancreatitis, bile duct obstruction, stomach ulcer, aphthous stomatitis[Ref], Very common (10% or more): Sensory neuropathy (54%), drowsiness/somnolence/sedation (37.5%), tremor (26%), dizziness/lightheadedness (23%), motor neuropathy (22%), headache (18.7%), depressed level of consciousness (16%), paresthesia (15.6%), sensory peripheral neuropathy (10%), Common (1% to 10%): Cerebrovascular accident/event, syncope, vertigo, abnormal coordination, transient ischemic event, ataxia, amnesia, causalgia, circumoral paresthesia, hyperesthesia, dysesthesia, Frequency not reported: Neuritis, peripheral neuritis, neuralgia, hypertonia, Postmarketing reports: Seizures, convulsions, Parkinson's disease/worsening of Parkinson's disease symptoms, posterior reversible encephalopathy syndrome (PRES)/reversible posterior leukoencephalopathy syndrome (RPLS), stupor, stroke, carpal tunnel, Raynaud's syndrome, migraine, foot drop[Ref], Very common (10% or more): Neutropenia (42.7%), decreased leukocytes (35%), decreased neutrophils (31%), leukopenia (25.8%), anemia (13.7%), lymphadenopathy (12.5%), lymphopenia (12.1%), thrombocytopenia (11.3%), Very rare (less than 0.01%): Eosinophilia, Frequency not reported: Increased/decreased platelet count, decreased erythrocyte sedimentation rate (ESR), granulocytopenia, hypochromic anemia, leukocytosis, elevated mean corpuscular volume (MCV), abnormal red blood cell (RBC) count, Postmarketing reports: Febrile neutropenia, pancytopenia, decreased white blood cell (WBC) count, prothrombin time changes, lymphedema[Ref], Very common (10% or more): Dyspnea (42%), pneumonia (15%), Common (1% to 10%): Bronchopneumonia, pulmonary embolism, pharyngitis, sinusitis, interstitial lung disease, Very rare (less than 0.01%): Bronchospasm, Frequency not reported: Cough, emphysema, epistaxis, rales, upper respiratory infection, voice alteration[Ref], Very common (10% or more): Muscle weakness (40%), myalgia (17%), arthralgia (13%), Frequency not reported: Upper extremity pain, arthritis, bone tenderness, joint disorder, leg cramps, myasthenia, periosteal disorder[Ref], Very common (10% or more): Rash/desquamation (30%), rash (25%), dry skin (21%), maculopapular rash (18.7%), sweating (12.5%), acne (11.1%), Common (1% to 10%): Fungal dermatitis, nail disorder, pruritus, toxic skin eruption, urticaria, Very rare (less than 0.01%): Severe skin reactions (Stevens-Johnson Syndrome, toxic epidermal necrolysis), facial edema, photosensitivity, alopecia, eczematous rash, exfoliative dermatitis, ichthyosis, perifollicular thickening, skin necrosis, seborrhea, sweating, vesiculobullous rash, Postmarketing reports: Erythema multiforme, erythema nodosum, purpura, petechiae[Ref], Very common (10% or more): Confusion (28%), anxiety/agitation (26%), depression (10%), Common (1% to 10%): Insomnia, nervousness, abnormal thinking, euphoria, impotence, altered mood/mood changes/mental status changes, Very rare (less than 0.01%): Decreased libido, Postmarketing reports: Sexual dysfunction, suicide attempts[Ref], Very common (10% or more): Thrombosis/embolism (22%), deep vein thrombosis (13%), Common (1% to 10%): Atrial fibrillation, myocardial ischemia/infarction, bradycardia, cardiac failure, hypotension, Uncommon (0.1% to 1%): Orthostatic hypotension, Rare (less than 0.1%): Tachycardia, cardiac arrhythmia, Frequency not reported: Hypertension, peripheral vascular disorder, vasodilation, cyanosis, Postmarketing reports: Atrioventricular block, pulmonary hypertension, sick sinus syndrome, electrocardiogram (ECG) abnormalities[Ref], Very common (10% or more): Hyperglycemia (15%), Very rare (less than 0.01%): Hypothyroidism, menstruation abnormalities, amenorrhea, Frequency not reported: Diabetes, inappropriate antidiuretic hormone (ADH), Postmarketing reports: Myxedema, galactorrhea, gynecomastia[Ref], Very common (10% or more): Abnormal bilirubin level (14%), increased SGOT (12.5%), Common (1% to 10%): Abnormal liver function tests, Frequency not reported: Enlarged liver, bilirubinemia, increased SGPT, Postmarketing reports: Increased alkaline phosphatase[Ref], Very common (10% or more): Hematuria (11.1%), Frequency not reported: Hyperuricemia, proteinuria, pyuria, urinary frequency, orchitis, Postmarketing reports: Oliguria, enuresis, metrorrhagia[Ref], Frequency not reported: Amblyopia, dry eye, eye pain, Postmarketing reports: Diplopia, nystagmus[Ref], Frequency not reported: Hypersensitivity/allergic reactions, angioedema[Ref], Frequency not reported: Viral reactivation (herpes zoster, hepatitis B, cytomegalovirus), increased HIV viral load/RNA levels, amyloidosis, Postmarketing reports: Viral infections[Ref], Frequency not reported: Acute myeloid leukemia, myelodysplastic syndromes, Postmarketing reports: Chronic myelogenous leukemia, nodular sclerosing Hodgkin's disease, erythroleukemia[Ref], Frequency not reported: Increased BUN, increased creatinine, Postmarketing reports: Renal failure, acute renal failure[Ref]. Epub 2021 Oct 21. sudden, unexplained shortness of breath. Significant differences are marked in comparison to vehicle (, Treatment of acneinduced PIH in darkskinned individuals. However, it apparently stands to reason that they would want their testing to be done by their own people, to prevent industrial espionage. The reaction is often immediate. shakiness in the legs, arms, hands, or feet. Certain ones may make the skin more sensitive to sunlight. Considering I have only used this product twice, I can't comment on the effectiveness, but I can say that it caused some redness on my otherwise super tolerant skin. Eucerin Anti-Pigment products contain Thiamidol and can be used alongside dermatological treatments such as chemical peels and laser therapies when skin is fully intact (and not wounded or open) to boost and extend results. The root cause of PiH is increased melanin production. Although these findings sound concerning, they dont prove that every product from these brands are always chock-full of benzine: There was significant variability from batch to batch, even within a single brand, the report states. 2020 Nov 13;12(3):363-369. doi: 10.1039/d0md00310g. Surg. ), The most likely theory is that benzene probably developed from a reaction caused from the propellant used to deliver the sunscreen from the bottle itself, Dr. Zeichner explains. Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild toModerate Melasma. But constant and daily sun protection will prevent new spots forming. Cancer awareness channel by Surgical oncologist Dr Dayananda Srinivasan, MS,DNB(Surg Oncology)For Appointments, Contact+91 95353 . La tyrosinase est lenzyme qui limite le taux de mlanognse. Johnson & Johnson is now recalling five Neutrogena and Aveeno SPF lines over benzene contamination. What causes drug-induced photosensitivity? Sprays, gels, and lotions with both chemical and mineral-based formulations contained benzene, Valisure wrote. Hoping to find some more resources then. For example, over 480,000 people die in the U.S. each year from smoking cigarettes, according to data reported in 2014. Popular options from brands like Banana Boat, Coppertone, Coola, EltaMD had no detectable carcinogens.
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